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KMID : 1140120120170040350
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Cancer Prevention Research
2012 Volume.17 No. 4 p.350 ~ p.358
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Useful Effect of Korean Bean Leaf on High Fat Diet-induced Nonalcoholic Steatohepatitis in the Rat: Immunohistochemistry Findings
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Hyun Kyung-Yae
Ju Mi-Ha
Choi Hwa-Sik
Choi Seok-Cheol
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Abstract
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Fatty liver with steatosis may cause metabolic syndrome and adult disease. We have undertaken this study to clarify the useful effect of Korean bean leaves on nonalcoholic steatohepatitis (NASH) in rats. After 8 weeks of the experiment, the body weights in the Bean-Leaf group (40%-fat+bean leaves diet, n=10) were greater than those of the Fat group (40%-fat diet, n=10). Serum triglyceride, glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and lactic dehydrogenase (LDH) levels in the Bean-Leaf group were significantly lower than those of the Fat group (p＜0.05). Light microphotographs of the liver (by Sudan black B stain) exhibited that fatty degeneration was less extensive in the Bean-Leaf group than in the Fat group. The expression levels of hepatic transforming growth factor-β1 (TGF-β1), cyclooxygenase-2 (COX-2), NADPH oxidase-4 (NOX-4), and poly (ADP-ribose) polymerase (PARP) genes were weaker, while the expression level of peroxiome proliferator-activated receptor-α (PPAR-α) gene was stronger in the Bean-Leaf group than in the Fat group. These results suggest that bean leaves-diet may ameliorate NASH-induced liver damage and that bean leaves may be food for preventing obesity and thereby metabolic syndrome and adult diseases.
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KEYWORD
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Nonalcoholic steatohepatitis, Korean bean leaf, Biochemistry, Liver injury
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